| --- |
| license: mit |
| configs: |
| - config_name: dataset |
| data_files: "dataset.csv" |
| --- |
| |
| ### Description |
| This dataset contains signle site mutation of protein DLG4_RAT amino acid sequence and the correspond mutation effect score from a deep mutation scanning experiment. |
| |
| **Protein Format:** AA sequence |
| |
| ### Splits |
| traing: 1325 |
| |
| valid: 159 |
| |
| test: 176 |
| |
| ### Related paper |
| The dataset is from [Deep generative models of genetic variation capture the effects of mutations](https://www.nature.com/articles/s41592-018-0138-4). |
| |
| ### Label |
| Label means fitness score of each mutant amino acid sequence based on a deep mutation scanning experiment. |
| The effect of each mutation is expressed as the log frequency of observing each amino acid x at each position i in the selected versus the unselected population, |
| relative to wild type. Ranging from negative infinity to positive infinity. If the effect larger than 0 represents high fitness, smaller than 0 represents low fitness. |
